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 Φάρμακα Α - Ζ  Συγχορήγηση  Μητρότητα

KLOR-CON Powder for oral solution (2020)

Αναφορές

Βιβλιογραφική αναφορά

Συγγραφείς

Upsher-Smith Laboratories, LLC

Λέξεις κλειδιά

0245-0360

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1. Indications and Usage

Klor-Con powder (potassium chloride) is indicated for the treatment and prophylaxis of hypokalemia with or without metabolic alkalosis, in patients for whom dietary management with potassium-rich foods ...

2. Dosage and Administration

2.1 Administration and Monitoring If serum potassium concentration is <2.5 mEq/L, use intravenous potassium instead of oral supplementation. Monitoring Monitor serum potassium and adjust dosages accordingly. ...

3. Dosage Forms and Strengths

Each packet contains 1.5 g of potassium chloride supplying 20 mEq of potassium and 20 mEq of chloride.

4. Contraindications

Klor-Con powder is contraindicated in patients on potassium sparing diuretics.

5. Warnings and Precautions

5.1 Gastrointestinal Irritation May cause gastrointestinal irritation. Increased dilution of the solution and taking with meals may reduce gastrointestinal irritation <em>[see Dosage and Administration ...

6. Adverse Reactions

The most common adverse reactions to oral potassium salts are nausea, vomiting, flatulence, abdominal pain/discomfort, and diarrhea.

7. Drug Interactions

7.1 Potassium-Sparing Diuretics Use with potassium-sparing diuretics can produce severe hyperkalemia. Avoid concomitant use. 7.2 Renin-Angiotensin-Aldosterone System Inhibitors Drugs that inhibit the renin-angiotensin-aldosterone ...

8. Use in Specific Populations

8.6 Cirrhotics Patients with cirrhosis should usually be started at the low end of the dosing range, and the serum potassium level should be monitored frequently <em>[see Clinical Pharmacology (12.3)] ...

8.1. Pregnancy

There are no human data related to use of Potassium Chloride during pregnancy, and animal studies have not been conducted. Potassium supplementation that does not lead to hyperkalemia is not expected to ...

8.2. Lactation

Risk Summary The normal potassium ion content of human milk is about 13 mEq per liter. Since potassium from oral supplements such as Potassium Chloride becomes part of the body potassium pool, as long ...

8.4. Pediatric Use

Clinical trial data from published literature have demonstrated the safety and effectiveness of potassium chloride in children with diarrhea and malnutrition from birth to 16 years.

8.5. Geriatric Use

Clinical studies of potassium chloride did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience ...

8.7. Renal Impairment

Patients with renal impairment have reduced urinary excretion of potassium and are at substantially increased risk of hyperkalemia. Patients with impaired renal function, particularly if the patient is ...

10. Overdosage

10.1 Symptoms The administration of oral potassium salts to persons with normal excretory mechanisms for potassium rarely causes serious hyperkalemia. However, if excretory mechanisms are impaired or if ...

11. Description

Potassium chloride is a white crystalline or colorless solid. It is soluble in water and slightly soluble in alcohol. Chemically, potassium chloride is KCl with a molecular mass of 74.55. Each packet of ...

12.1. Mechanism of Action

The potassium ion (K<sup>+</sup>) is the principal intracellular cation of most body tissues. Potassium ions participate in a number of essential physiological processes including the maintenance of intracellular ...

12.3. Pharmacokinetics

Based on published literature, the rate of absorption and urinary excretion of potassium from KCl oral solution were higher during the first few hours after dosing relative to modified release KCl products. ...

16.1. How Supplied

Klor-Con powder (potassium chloride for oral solution, USP) is a light orange powder available in one strength as follows: 20 mEq Each packet contains 1.5 g of potassium chloride providing potassium 20 ...

16.2. Storage and Handling

Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in tight, light-resistant container as defined in the USP. PROTECT ...