TIGAN Solution for injection (2020)

Βιβλιογραφική αναφορά

Συγγραφείς

HF Acquisition Co LLC, DBA HealthFirst

Λέξεις κλειδιά

51662-1430

Για την προβολή της πλήρους καταχώρησης απαιτείται συνδρομή σε ισχύ.
Αποκτήστε πρόσβαση σε όλες τις πληροφορίες και τα εργαλεία του Galinos.gr δωρεάν για έναν μήνα απλά κάνοντας εγγραφή.
Δωρεάν εγγραφή

1. Description

Chemically, trimethobenzamide hydrochloride (HCl) is N-[p-[2-(dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxybenzamide monohydrochloride. It has a molecular weight of 424.93 and the following structural ...

2. Clinical Pharmacology

Mechanism of Action The mechanism of action of Tigan as determined in animals is obscure, but may involve the chemoreceptor trigger zone (CTZ), an area in the medulla oblongata through which emetic impulses ...

3. Indications and Usage

Tigan is indicated for the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.

4. Contraindications

The injectable form of Tigan is contraindicated in pediatric patients and in patients with known hypersensitivity to trimethobenzamide.

5. Warnings

Tigan may produce drowsiness. Patients should not operate motor vehicles or other dangerous machinery until their individual responses have been determined. Usage in Pregnancy Trimethobenzamide hydrochloride ...

6. Precautions

During the course of acute febrile illness, encephalitides, gastroenteritis, dehydration and electrolyte imbalance, especially in children and the elderly or debilitated, CNS reactions such as opisthotonos, ...

6.1. General

Adjustment of Dose in Renal Failure A substantial route of elimination of unchanged trimethobenzamide is via the kidney. Dosage adjustment should be considered in patients with reduced renal function including ...

7. Adverse Reactions

There have been reports of hypersensitivity reactions and Parkinson-like symptoms. There have been instances of hypotension reported following parenteral administration to surgical patients. There have ...

10. Dosage and Administration

(See WARNINGS and PRECAUTIONS.) Dosage should be adjusted according to the indication for therapy, severity of symptoms and the response of the patient. Geriatric Patients Dose adjustment such as reducing ...

11. How Supplied

TIGAN==== (TRIMETHOBENZAMIDE HYDROCHLORIDE) INJECTION is supplied in the following dosage forms. NDC 51662-1430-1 TIGAN==== (TRIMETHOBENZAMIDE HYDROCHLORIDE) INJECTION 200mg/2mL (100mg/mL) 2mL VIAL HF ...

12. Storage and handling

Store between 20° to 25°C (68° to 77°F). (See USP Controlled Room Temperature)